JAMA Network Open: Neuropsychiatric Symptoms and Microglial Activation in Patients with Alzheimer Disease | UPMC Physician Resources

• In collaboration with colleagues, Tharick Pascoal, MD, PhD, associate professor of Neurology and Psychiatry, studied the association between neuropsychiatric symptoms and glial markers (microglial activation and astrocyte reactivity), in individuals with Alzheimer’s.

New Publication Features Neurodegenerative Disease Research | UPMC Physician Resources

• Pitt researchers are working to discover effective treatments for a rapidly progressive and incurable neurodegenerative disease. In a paper published in Nature Communications, a team led by professor of neurology and UPMC Endowed Chair of movement disorders Edward A. Burton, MD, DPhil, FRCP, developed a novel zebrafish model of progressive supranuclear palsy (PSP).

Reproductive Health and Epilepsy | UPMC Physician Resources

• A study published in Neurology Clinical Practice examined the knowledge and attitudes of health care providers and women with epilepsy (WWE) regarding reproductive health. It revealed low confidence among providers in managing pregnancy for WWE and limited awareness of recent research findings. The study highlights a critical need for improved education and dissemination of updated research to support informed decision-making and better outcomes for WWE. Laura Kirkpatrick, MD, assistant professor of pediatrics with a secondary appointment in neurology at the University of Pittsburgh School of Medicine, was lead author of the study.

Other 2024 Publications

• Hernández-Díaz S, Straub L, Bateman BT, Zhu Y, Mogun H, Wisner KL, Gray KJ, Lester B, McDougle CJ, DiCesare E, Pennell PB, Huybrechts KF.

Risk of Autism after Prenatal Topiramate, Valproate, or Lamotrigine Exposure. N Engl J Med. 2024 Mar 21;390(12):1069-1079. doi: 10.1056/NEJMoa2309359. PMID: 38507750; PMCID: PMC11047762.

• Linnoila JJ, Rapalino O, Walker MA, Martinez-Lage M.

Case 12-2024: A 58-Year-Old Woman with Confusion, Aphasia, and Abnormal Head Imaging. N Engl J Med. 2024 Apr 18;390(15):1421-1430. doi: 10.1056/NEJMcpc2312732. PMID: 38631006.

• Smith EE, Rohatgi S, Linnoila JJ, Martinez-Lage M.

Case 23-2024: A 78-Year-Old Woman with Rapidly Progressive Dementia. N Engl J Med. 2024 Jul 25;391(4):357-369. doi: 10.1056/NEJMcpc2402488. PMID: 39047245.

• Shen Y, Timsina J, Heo G, Beric A, Ali M, Wang C, Yang C, Wang Y, Western D, Liu M, Gorijala P, Budde J, Do A, Liu H, Gordon B, Llibre-Guerra JJ, Joseph-Mathurin N, Perrin RJ, Maschi D, Wyss-Coray T, Pastor P, Renton AE, Surace EI, Johnson ECB, Levey AI, Alvarez I, Levin J, Ringman JM, Allegri RF, Seyfried N, Day GS, Wu Q, Fernández MV, Tarawneh R, McDade E, Morris JC, Bateman RJ, Goate A; Dominantly Inherited Alzheimer Network (Sarah B Berman); Ibanez L, Sung YJ, Cruchaga C. CSF proteomics identifies early changes in autosomal dominant Alzheimer's disease. Cell. 2024 Oct 31;187(22):6309-6326.e15. doi: 10.1016/j.cell.2024.08.049. Epub 2024 Sep 26. PMID: 39332414; PMCID: PMC11531390.

• Johnston MJ, Lee JJY, Hu B, Nikolic A, Hasheminasabgorji E, Baguette A, Paik S, Chen H, Kumar S, Chen CCL, Jessa S, Balin P, Fong V, Zwaig M, Michealraj KA, Chen X, Zhang Y, Varadharajan S, Billon P, Juretic N, Daniels C, Rao AN, Giannini C, Thompson EM, Garami M, Hauser P, Pocza T, Ra YS, Cho BK, Kim SK, Wang KC, Lee JY, Grajkowska W, Perek-Polnik M, Agnihotri S, Mack S, Ellezam B, Weil A, Rich J, Bourque G, Chan JA, Yong VW, Lupien M, Ragoussis J, Kleinman C, Majewski J, Blanchette M, Jabado N, Taylor MD, Gallo M.

TULIPs decorate the three-dimensional genome of PFA ependymoma. Cell. 2024 Sep 5;187(18):4926-4945.e22. doi: 10.1016/j.cell.2024.06.023. Epub 2024 Jul 9. PMID: 38986619.

• Visvanathan A, Saulnier O, Chen C, Haldipur P, Orisme W, Delaidelli A, Shin S, Millman J, Bryant A, Abeysundara N, Wu X, Hendrikse LD, Patil V, Bashardanesh Z, Golser J, Livingston BG, Nakashima T, Funakoshi Y, Ong W, Rasnitsyn A, Aldinger KA, Richman CM, Van Ommeren R, Lee JJY, Ly M, Vladoiu MC, Kharas K, Balin P, Erickson AW, Fong V, Zhang J, Suárez RA, Wang H, Huang N, Pallota JG, Douglas T, Haapasalo J, Razavi F, Silvestri E, Sirbu O, Worme S, Kameda-Smith MM, Wu X, Daniels C, MichaelRaj AK, Bhaduri A, Schramek D, Suzuki H, Garzia L, Ahmed N, Kleinman CL, Stein LD, Dirks P, Dunham C, Jabado N, Rich JN, Li W, Sorensen PH, Wechsler-Reya RJ, Weiss WA, Millen KJ, Ellison DW, Dimitrov DS, Taylor MD.

Early rhombic lip Protogenin^+ve stem cells in a human-specific neurovascular niche initiate and maintain group 3 medulloblastoma. Cell. 2024 Aug 22;187(17):4733-4750.e26. doi: 10.1016/j.cell.2024.06.011. Epub 2024 Jul 5. PMID: 38971152.

• MARVEL Trial Authors for the MARVEL Investigators; Yang Q, Guo C, Yue C, Song J, Yang J, Peng Z, Yu N, Huang J, Li L, Huang J, Chen Y, Zheng C, Jiang S, Ruan Z, Zhang M, Song D, Luo X, Tian Y, Yang M, Deng S, Wei S, Wu Y, Tang Y, Yang D, Tan X, Zeng G, Cheng D, Liu W, He W, Cai T, Pan C, Liao J, Lei B, Pu S, Jin Z, Li J, Xia Z, Zhang G, Luo J, Sun Y, Xiong X, Wang J, Li B, Peng Y, Chen K, Shan Y, Zhou P, Huang X, Luo S, Zhang J, Liu C, Jiang L, Yang D, Tian Y, Hu J, Qiu Z, Ma J, Xu X, Fan S, Liu X, Xie D, Niu J, Zheng H, Ouyang Q, Wang D, Nguyen TN, Saver JL, Nogueira RG, Li F, Zi W. Methylprednisolone as Adjunct to Endovascular Thrombectomy for Large-Vessel Occlusion Stroke: The MARVEL Randomized Clinical Trial. JAMA. 2024 Mar 12;331(10):840-849. doi: 10.1001/jama.2024.0626. PMID: 38329440; PMCID: PMC10853866.

• Kamel H, Longstreth WT Jr, Tirschwell DL, Kronmal RA, Marshall RS, Broderick JP, Aragón García R, Plummer P, Sabagha N, Pauls Q, Cassarly C, Dillon CR, Di Tullio MR, Hod EA, Soliman EZ, Gladstone DJ, Healey JS, Sharma M, Chaturvedi S, Janis LS, Krishnaiah B, Nahab F, Kasner SE, Stanton RJ, Kleindorfer DO, Starr M, Winder TR, Clark WM, Miller BR, Elkind MSV; ARCADIA Investigators.

Apixaban to Prevent Recurrence After Cryptogenic Stroke in Patients With Atrial Cardiopathy: The ARCADIA Randomized Clinical Trial. JAMA. 2024 Feb 20;331(7):573-581. doi: 10.1001/jama.2023.27188. PMID: 38324415; PMCID: PMC10851142.

• GBD 2021 Nervous System Disorders Collaborators (Mohamed Fahmy Doheim).

Global, regional, and national burden of disorders affecting the nervous system, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet Neurol. 2024 Apr;23(4):344-381. doi: 10.1016/S1474-4422(24)00038-3. Epub 2024 Mar 14. Erratum in: Lancet Neurol. 2024 May;23(5):e9. doi: 10.1016/S1474-4422(24)00114-5. Erratum in: Lancet Neurol. 2024 Jul;23(7):e11. doi: 10.1016/S1474-4422(24)00231-X. PMID: 38493795; PMCID: PMC10949203.

• Schultz SA, Liu L, Schultz AP, Fitzpatrick CD, Levin R, Bellier JP, Shirzadi Z, Joseph-Mathurin N, Chen CD, Benzinger TLS, Day GS, Farlow MR, Gordon BA, Hassenstab JJ, Jack CR Jr, Jucker M, Karch CM, Lee JH, Levin J, Perrin RJ, Schofield PR, Xiong C, Johnson KA, McDade E, Bateman RJ, Sperling RA, Selkoe DJ, Chhatwal JP; Dominantly Inherited Alzheimer Network (Sarah B Berman).

γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS). Lancet Neurol. 2024 Sep;23(9):913-924. doi: 10.1016/S1474-4422(24)00236-9. Epub 2024 Jul 26. PMID: 39074479.

• Simuni T, Chahine LM, Poston K, Brumm M, Buracchio T, Campbell M, Chowdhury S, Coffey C, Concha-Marambio L, Dam T, DiBiaso P, Foroud T, Frasier M, Gochanour C, Jennings D, Kieburtz K, Kopil CM, Merchant K, Mollenhauer B, Montine T, Nudelman K, Pagano G, Seibyl J, Sherer T, Singleton A, Stephenson D, Stern M, Soto C, Tanner CM, Tolosa E, Weintraub D, Xiao Y, Siderowf A, Dunn B, Marek K.

A biological definition of neuronal α-synuclein disease: towards an integrated staging system for research. Lancet Neurol. 2024 Feb;23(2):178-190. doi: 10.1016/S1474-4422(23)00405-2. PMID: 38267190.

• Simuni T, Chahine LM, Weintraub D, Poston KM, Kopil CM, Dunn B, Marek K. Concerns with the new biological research criteria for synucleinopathy - Authors' reply. Lancet Neurol. 2024 Jul;23(7):663-666. doi: 10.1016/S1474-4422(24)00233-3. PMID: 38876741.

• Allen JA, Lin J, Basta I, Dysgaard T, Eggers C, Guptill JT, Gwathmey KG, Hewamadduma C, Hofman E, Hussain YM, Kuwabara S, Le Masson G, Leypoldt F, Chang T, Lipowska M, Lowe M, Lauria G, Querol L, Simu MA, Suresh N, Tse A, Ulrichts P, Van Hoorick B, Yamasaki R, Lewis RA, van Doorn PA; ADHERE Study Group  (David Lacomis).

Safety, tolerability, and efficacy of subcutaneous efgartigimod in patients with chronic inflammatory demyelinating polyradiculoneuropathy (ADHERE): a multicentre, randomised-withdrawal, double-blind, placebo-controlled, phase 2 trial. Lancet Neurol. 2024 Oct;23(10):1013-1024. doi: 10.1016/S1474-4422(24)00309-0. PMID: 39304241.

• Narayanaswami P, Sanders DB, Thomas L, Thibault D, Blevins J, Desai R, Krueger A, Bibeau K, Liu B, Guptill JT; PROMISE-MG Study Group (David Lacomis).

Comparative effectiveness of azathioprine and mycophenolate mofetil for myasthenia gravis (PROMISE-MG): a prospective cohort study. Lancet Neurol. 2024 Mar;23(3):267-276. doi: 10.1016/S1474-4422(24)00028-0. PMID: 38365379.

• Sheth KN, Albers GW, Saver JL, Campbell BCV, Molyneaux BJ, Hinson HE, Cordonnier C, Steiner T, Toyoda K, Wintermark M, Littauer R, Collins J, Lucas N, Nogueira RG, Simard JM, Wald M, Dawson K, Kimberly WT; CHARM Trial investigators.

Intravenous glibenclamide for cerebral oedema after large hemispheric stroke (CHARM): a phase 3, double-blind, placebo-controlled, randomised trial. Lancet Neurol. 2024 Dec;23(12):1205-1213. doi: 10.1016/S1474-4422(24)00425-3. Erratum in: Lancet Neurol. 2025 Jan;24(1):e1. doi: 10.1016/S1474-4422(24)00495-2. PMID: 39577921.

• Nogueira RG, Jovin TG, Liu X, Hu W, Langezaal LCM, Li C, Dai Q, Tao C, Mont'Alverne FJA, Ji X, Liu R, Li R, Dippel DWJ, Wu C, Zhu W, Xu P, van Zwam WH, Wu L, Zhang C, Michel P, Chen J, Wang L, Puetz V, Zhao W, Liu T, Audebert HJ, Chen Z, Pontes-Neto OM, Yi T, Moran TP, Doheim MF, Schonewille WJ; ATTENTION, BASICS, BAOCHE, and BEST Investigators. Endovascular therapy for acute vertebrobasilar occlusion (VERITAS): a systematic review and individual patient data meta-analysis. Lancet. 2024 Dec 11:S0140-6736(24)01820-8. doi: 10.1016/S0140-6736(24)01820-8. Epub ahead of print. PMID: 39674187.

• GBD 2021 Nervous System Disorders Collaborators (Mohamed Fahmy Doheim).

Global, regional, and national burden of disorders affecting the nervous system, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet Neurol. 2024 Apr;23(4):344-381. doi: 10.1016/S1474-4422(24)00038-3. Epub 2024 Mar 14. Erratum in: Lancet Neurol. 2024 May;23(5):e9. doi: 10.1016/S1474-4422(24)00114-5. Erratum in: Lancet Neurol. 2024 Jul;23(7):e11. doi: 10.1016/S1474-4422(24)00231-X. PMID: 38493795; PMCID: PMC10949203.

• Sarraj A, Abraham MG, Hassan AE, Blackburn S, Kasner SE, Ortega-Gutierrez S, Hussain MS, Chen M, Johns H, Churilov L, Pujara DK, Shaker F, Maali L, Cardona Portela P, Herial NA, Gibson D, Kozak O, Arenillas JF, Yan B, Pérez de la Ossa N, Sundararajan S, Hu YC, Cordato DJ, Manning NW, Hanel RA, Aghaebrahim AN, Budzik RF, Hicks WJ, Blasco J, Wu TY, Tsai JP, Schaafsma JD, Gandhi CD, Al-Mufti F, Sangha N, Warach S, Kleinig TJ, Yogendrakumar V, Ng F, Samaniego EA, Abdulrazzak MA, Parsons MW, Rahbar MH, Nguyen TN, Fifi JT, Mendes Pereira V, Lansberg MG, Albers GW, Furlan AJ, Jabbour P, Sitton CW, Sila C, Bambakidis N, Davis SM, Wechsler L, Hill MD, Grotta JC, Ribo M, Campbell BCV; SELECT2 Investigators. Endovascular thrombectomy plus medical care versus medical care alone for large ischaemic stroke: 1-year outcomes of the SELECT2 trial. Lancet. 2024 Feb 24;403(10428):731-740. doi: 10.1016/S0140-6736(24)00050-3. Epub 2024 Feb 9. PMID: 38346442.

• Kim JJ, Vitale D, Otani DV, Lian MM, Heilbron K; 23andMe Research Team; Iwaki H, Lake J, Solsberg CW, Leonard H, Makarious MB, Tan EK, Singleton AB, Bandres-Ciga S, Noyce AJ; Global Parkinson’s Genetics Program (GP2) (Chahine LM); Blauwendraat C, Nalls MA, Foo JN, Mata I.

Multi-ancestry genome-wide association meta-analysis of Parkinson's disease. Nat Genet. 2024 Jan;56(1):27-36. doi: 10.1038/s41588-023-01584-8. Epub 2023 Dec 28. PMID: 38155330; PMCID: PMC10786718.

• García-Marín LM, Campos AI, Diaz-Torres S, Rabinowitz JA, Ceja Z, Mitchell BL, Grasby KL, Thorp JG, Agartz I, Alhusaini S, Ames D, Amouyel P, Andreassen OA, Arfanakis K, Arias-Vasquez A, Armstrong NJ, Athanasiu L, Bastin ME, Beiser AS, Bennett DA, Bis JC, Boks MPM, Boomsma DI, Brodaty H, Brouwer RM, Buitelaar JK, Burkhardt R, Cahn W, Calhoun VD, Carmichael OT, Chakravarty M, Chen Q, Ching CRK, Cichon S, Crespo-Facorro B, Crivello F, Dale AM, Smith GD, de Geus EJC, De Jager PL, de Zubicaray GI, Debette S, DeCarli C, Depondt C, Desrivières S, Djurovic S, Ehrlich S, Erk S, Espeseth T, Fernández G, Filippi I, Fisher SE, Fleischman DA, Fletcher E, Fornage M, Forstner AJ, Francks C, Franke B, Ge T, Goldman AL, Grabe HJ, Green RC, Grimm O, Groenewold NA, Gruber O, Gudnason V, Håberg AK, Haukvik UK, Heinz A, Hibar DP, Hilal S, Himali JJ, Ho BC, Hoehn DF, Hoekstra PJ, Hofer E, Hoffmann W, Holmes AJ, Homuth G, Hosten N, Ikram MK, Ipser JC, Jack CR Jr, Jahanshad N, Jönsson EG, Kahn RS, Kanai R, Klein M, Knol MJ, Launer LJ, Lawrie SM, Hellard SL, Lee PH, Lemaître H, Li S, Liewald DCM, Lin H, Longstreth WT Jr, Lopez OL, Luciano M, Maillard P, Marquand AF, Martin NG, Martinot JL, Mather KA, Mattay VS, McMahon KL, Mecocci P, Melle I, Meyer-Lindenberg A, Mirza-Schreiber N, Milaneschi Y, Mosley TH, Mühleisen TW, Müller-Myhsok B, Maniega SM, Nauck M, Nho K, Niessen WJ, Nöthen MM, Nyquist PA, Oosterlaan J, Pandolfo M, Paus T, Pausova Z, Penninx BWJH, Pike GB, Psaty BM, Pütz B, Reppermund S, Rietschel MD, Risacher SL, Romanczuk-Seiferth N, Romero-Garcia R, Roshchupkin GV, Rotter JI, Sachdev PS, Sämann PG, Saremi A, Sargurupremraj M, Saykin AJ, Schmaal L, Schmidt H, Schmidt R, Schofield PR, Scholz M, Schumann G, Schwarz E, Shen L, Shin J, Sisodiya SM, Smith AV, Smoller JW, Soininen HS, Steen VM, Stein DJ, Stein JL, Thomopoulos SI, Toga AW, Tordesillas-Gutiérrez D, Trollor JN, Valdes-Hernandez MC, van T Ent D, van Bokhoven H, van der Meer D, van der Wee NJA, Vázquez-Bourgon J, Veltman DJ, Vernooij MW, Villringer A, Vinke LN, Völzke H, Walter H, Wardlaw JM, Weinberger DR, Weiner MW, Wen W, Westlye LT, Westman E, White T, Witte AV, Wolf C, Yang J, Zwiers MP, Ikram MA, Seshadri S, Thompson PM, Satizabal CL, Medland SE, Rentería ME.

Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries. Nat Genet. 2024 Nov;56(11):2333-2344. doi: 10.1038/s41588-024-01951-z. Epub 2024 Oct 21. PMID: 39433889.

View the full list of publications from Department faculty in 2024.

• UPMC Department of Neurology Presentations at AAN 2024 | UPMC Physician Resources
  • The UPMC Department of Neurology was well-represented at the American Academy of Neurology annual meeting, which occurred in Denver, April 13-18, with a variety of poster sessions, seminars, and scientific platform sessions. Our faculty showcased their clinical and research expertise, with topics ranging from epilepsy, multiple sclerosis, stroke care, migraines, pregnancy and neurologic conditions, and more. View the full list of participation.

     

• UPMC Department of Neurology Faculty Attend AUPN 2024 | UPMC Physician Resources
  • Department of Neurology faculty attended and participated in the Association of University Professors of Neurology (AUPN) annual meeting on September 14 to 16, 2024. Our faculty shared their expertise through speaking sessions and posters throughout the event.

     

• UPMC Hosts 2024 EEG and Epilepsy in Clinical Practice Event Review | UPMC Physician Resources
  • In conjunction with the University of Pittsburgh Department of Neurology and the UPMC Center for Clinical Neurophysiology, Procirca and course co-directors Anto Bagic MD, PhD, and Alexandra Urban, MD, hosted the 2024 EEG and Epilepsy in Clinical Practice course September 27 to 28, 2024.

    The event provided an opportunity for professionals to expand their knowledge and acquire and improve competencies for providing care to patients with epilepsy and related conditions.  This course was an intensive two-day course designed to introduce core clinical epilepsy and EEG, as well as cutting edge pre-surgical evaluation techniques for drug resistant epilepsies.

     

• UPMC Hosts Multiple Sclerosis Symposium | UPMC Physician Resources
  • On October 4, 2024, the UPMC Department of Neurology hosted the Multiple Sclerosis Symposium: Clinical Advances of Multiple Sclerosis Diagnosis and Treatment, a one-day symposium highlighting innovations and advances in multiple sclerosis (MS) care.

    Under the direction of nationally renowned leader in MS care and treatment, Ingrid Loma-Miller, MD, alongside co-director Emily Guerriero, PA-C, the symposium was centered around current state-of-the-art treatment methods and the future of MS care.

     

• UPMC Departments of Neurology and Neurosurgery Participated in AES | UPMC Physician Resources
  • The UPMC Departments of Neurology and Neurosurgery had a prominent presence at the 2024 Annual Meeting of the American Epilepsy Society (AES), taking place from December 6 to 10 in Los Angeles, California. Our experts led and participated in educational sessions, showcasing their expertise and advancing the field of epilepsy care and research. View the full list of UPMC and University of Pittsburgh participation here.