New Brain Cell Atlas Offers Precision Medicine Framework for TBI Treatment

A multidisciplinary group of investigators at the University of Pittsburgh and Barrow Neurological Institute in Phoenix created an interactive molecular atlas of traumatic brain injury, or TBI, in mice, which may help doctors use precision medicine to target treatments for TBI patients in the future. This research was published this week in Neuron.

Dr. Patrick Kochanek, distinguished professor, vice chair of critical care medicine and director of the Safar Center at Pitt, Dr. Gary Kohanbash, assistant professor of neurological surgery and expert on single-cell RNA sequencing and brain tumor biology in the Department of Neurological Surgery at Pitt, and Dr. Dhivyaa Rajasundaram, director of the UPMC Children’s Hospital of Pittsburgh Bioinformatics Core, were the study's co-senior authors.

Researchers explored the cell-specific complexity of response to a TBI – including the effect of distance from the impact site and time from injury.

For more details, read the full release here.