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Recent Research Publications from the Division of Gastroenterology, Hepatology and Nutrition at UPMC Children’s Hospital of Pittsburgh

June 23, 2024

Below is a selection of recent research from faculty in the Division of Pediatric Gastroenterology, Hepatology and Nutrition at UPMC Children’s published during the first half of 2024.

Transplant-Related Research

Impact of early immunosuppression on pediatric liver transplant outcomes within 1 year.

Raghu VK, Zhang X, Squires JE, Eisenberg E, Feldman AG, Halma J, Peters AL, Gonzalez-Peralta RP, Ng VL, Horslen SP, Lobritto SJ, Bucuvalas J, Mazariegos GV, Perito ER. J Pediatr Gastroenterol Nutr. 2024 Feb; 78(2): 328-338.

Improved mortality prediction for pediatric acute liver failure using dynamic prediction strategy.

Li R, Wang J, Zhang C, Squires JE, Belle SH, Ning J, Cai J, Squires RH. J Pediatr Gastroenterol Nutr. 2024 Feb;78(2):320-327. d

Patient-centered research in pediatric transplant: Engaging families and recipients.

Perito ER, McQueen M, Lau J, Krise-Confair C, Hillenburg JP, Mazariegos G, Squires JE. Am J Transplant. 2024 May;24(5):857-864.

Kidney transplant in pediatric gut transplant recipients - Technical challenges and outcomes.

Amin A, Emmanuel B, Raghu V, Khanna A, Soltys K, Sindhi R, Tevar A, Moritz ML, Humar A, Mazariegos G, Ganoza A. Pediatr Transplant. 2024 May; 28(3): e14744.

Nutrition support considerations in pediatric small bowel transplantation.

Nucci AM, Crim K, King E, Ganoza AJ, Remaley L, Rudolph J. Nutr Clin Pract. 2024 Feb; 39(1): 75-85.

Hepatology- Related Research

Maralixibat in progressive familial intrahepatic cholestasis (MARCH-PFIC): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.

Miethke AG, Moukarzel A, Porta G, Covarrubias Esquer J, Czubkowski P, Ordonez F, Mosca A, Aqul AA, Squires RH, Sokal E, D'Agostino D, Baumann U, D'Antiga L, Kasi N, Laborde N, Arikan C, Lin CH, Gilmour S, Mittal N, Chiou FK,Horslen SP, Huber WD, Jaecklin T, Nunes T, Lascau A, Longpre L, Mogul DB, Garner W, Vig P, Hupertz VF, Gonzalez-Peralta RP, Ekong U, Hartley J, Laverdure N, Ovchinsky N, Thompson RJ. Lancet Gastroenterol Hepatol. 2024 Jul; 9(7): 620-631.

Diagnostic accuracy of serum matrix metalloproteinase-7 as a biomarker of biliary atresia in a large North American cohort.

Pandurangi S, Mourya R, Nalluri S, Fei L, Dong S, Harpavat S, Guthery SL, Molleston JP, Rosenthal P, Sokol RJ, Wang KS, Ng V, Alonso EM, Hsu EK, Karpen SJ, Loomes KM, Magee JC, Shneider BL,Horslen SP, Teckman JH, Bezerra JA; Childhood Liver Disease Research Network. Hepatology. 2024 Jul 1; 80(1): 152-162.

Other Research Areas

High prevalence of gastrointestinal disorders in a large cohort of patients with joint hypermobility.

Sood V, Kaul A, El-Chammas KI, Mukkada VA, Sun Q, Fei L, Santucci NR. J Pediatr Gastroenterol Nutr. 2024 May 15. doi: 10.1002/jpn3.12245. Online ahead of print.