New Faculty Publications on Pancreatic Cancer and Liver Disease Treatment
January 7, 2025
Two recent impactful studies recently published by faculty within the Division of Gastroenterology, Hepatology and Nutrition provided valuable insights into pancreatic cancer and liver disease treatment.
Unraveling the Genetic Links in Pancreatic Cancer
Publication: The role of family history in predicting germline pathogenic variant carriers who develop pancreatic cancer: Results of a multicenter collaboration.
UPMC/Pitt authors: Randall E. Brand, MD, Beth Dudley Yurkovich, MS, MPH, CGC, and Eve Karloski, MS
Journal: Cancer (2024 Oct 1; 130(19): 3297-3304)
This multicenter study highlights the critical role of family history in identifying carriers of germline pathogenic variants who are at an elevated risk of developing pancreatic cancer. By pooling data from multiple centers, the researchers provided a robust evaluation of genetic predisposition, offering a step forward in risk stratification and early detection strategies. These findings underscore the importance of integrating genetic counseling and testing into routine clinical practice, particularly for individuals with a strong family history of pancreatic cancer.
Optimizing TIPS Use for Acute Variceal Bleeding
Publication: Challenges and Opportunities in the Adoption of p-TIPS for Acute Variceal Bleeding: Insights from a US Tertiary Center.
UPMC/Pitt authors: Stela Celaj, MD, Naudia L. Jonassaint, MD, Paula Novelli, MD, Philip Orons, DO, Ali Al-Khafaji, MD, and Ruy J. Cruz, MD, PhD.
Journal: Digestive Diseases and Sciences (2024 Nov 25)
Portal vein Transjugular Intrahepatic Portosystemic Shunt (p-TIPS) is an emerging approach for managing acute variceal bleeding. This study, conducted at a US tertiary center, delves into the practical challenges and opportunities associated with adopting this advanced procedure. The authors address key barriers, including procedural complexity, patient selection, and institutional resources, while identifying pathways to optimize outcomes. Their insights provide a roadmap for healthcare systems seeking to implement this life-saving technology effectively.
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